Intervertebral disk degeneration (IDD) is strongly associated with genetic predisposition and environmental susceptibility. Several studies been conducted to investigate the potential association between IDD and FokI polymorphism located in the gene encoding the vitamin D receptor (VDR), and inconsistent conclusions had been reached among different ethnic populations. In order to assess the association between the FokI polymorphism and the risk of IDD, we performed a comprehensive and systematic meta-analysis. Candidate articles were retrieved from PubMed, EMBASE, China National Knowledge Infrastructure (CNKI), and China Biology Medical (CBM) with strict inclusion criteria in January 2015. Among the 54 articles that were retrieved, only eight studies met the inclusion criteria. The pooled data analysis based on allele contrast, homozygote, heterozygote, dominant, and recessive models revealed no significant correlation between the FokI polymorphism and the risk of IDD. However, when stratified by ethnicity, significant associations were detected for Hispanics based on allele contrast (OR = 1.395, 95% CI = 1.059–1.836, P = 0.018), homozygote (OR = 1.849, 95% CI = 1.001–3.416, P = 0.049), heterozygote (OR = 1.254, 95% CI = 1.049–1.498, P = 0.013), and dominant (OR = 1.742, 95% CI = 1.174–2.583, P = 0.006) models, and for Asians using the dominant model (OR = 1.293, 95% CI = 1.025–1.632, P = 0.030), whereas there is no significant association detected for Caucasians. In conclusion, FokI polymorphism is not generally associated with IDD, but there is increased risk for IDD in Hispanics and Asians carrying FokI allele T.
椎间盘变性(Intervertebral disk degeneration，IDD)与遗传易感性和环境敏感性密切相关。当前有许多研究探索IDD和维生素D受体(VDR) FokI多态性的潜在关联,但是这些研究结果并不一致。为了系统评估FokI多态性和IDD的相关性,我们进行了全面、系统文献回顾和Meta分析。我们检索了PubMed、EMBASE、(CNKI),和(CBM)数据库，时间节点为2015年1月。在检索到的54篇文章中,只有8个研究符合入选标准。基于等位基因,纯合子,杂合子,显性和隐性模型，探究FokI多态性和IDD相关性。研究发现，在拉美人群中FokI多态性和IDD存在相关性(等位基因模型，OR= 1.395,95% CI = 1.059 - -1.836,P = 0.018；纯合子模型OR= 1.849,95% CI = 1.001 - -3.416,P = 0.049;杂合子模型,OR= 1.254,95% CI = 1.049 - -1.498,P = 0.013;显性模型,OR= 1.742,95% CI = 1.174 - -2.583,P = 0.006)。在亚洲人中，我们也探索到显著相关性(显性基因模型，OR= 1.293,95% CI = 1.025 - -1.632,P = 0.030);然而在高加索人群中没有发现相关性。本次研究得出, 拉美裔和亚裔携带FokI T等位基因的个体，IDD风险显著要高。